23.8.2026
Reading time:
3 min

Botulinum Toxin Treatment - Guideline

ONO Medical Board

Dr. Valery Vinzent Wittwer

Indications

  • eyelid blepharospasm/hemifacial spasm
  • chemical denervation of the upper lid in severe keratitis
  • cosmetic purposes (reduce frown lines, forehead lines, chemical brow lifting, crow's feet, bar code lines, DAO, platysma bands, etc.)

Differential diagnosis

  • rhytides resulting from tissue laxity (not dynamic)
  • dermatochalasis, palpebral ptosis
  • eyebrow ptosis

Pretreatment

  • diagnosis (including good quality frontal and side pictures, dynamic pictures)
  • consent form: always mention risk of bruising, eyelid ptosis, asymmetry, touch-up
  • align expectations with realistic results; identify patients with high expectations or dysmorphophobia
  • +PLUS (additional self-pay treatments): consider offering adjuvant cosmetic therapies such as fillers, collagen stimulators, eyelid or brow surgery
  • anticoagulation: no need to adjust

Required material

  • treatment basin (disposable or not)
  • 10x10cm gauze
  • make-up remover (micellar water)
  • Octenisept® disinfecting solution
  • marking pen (white eyeliner)
  • botulinum toxin (Vistabel®)
  • saline solution (NaCl) for dilution
  • 3ml syringe for dilution
  • 1ml or 0.3ml insulin syringe for treatment
  • 30G-34G needles depending on muscle

Procedure

  • patient in sitting position
  • dilution of toxin: usually 2.5ml NaCl for 100 units Vistabel®
  • cleanse skin, remove make-up
  • mark injection points according to indication
  • disinfect skin with Octenisept® and gauze
  • inject botulinum toxin with fine needle (30G-34G)
  • press on skin in case of bruising
  • cleanse skin and apply SPF 50

Post procedure

  • elevate head, avoid sport and sauna on the same day
  • touch-up if needed on day 12-14 after treatment

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