19.4.2025
Reading time:
15 Min.

IOL Power Calculation Guideline (ONO)

Determining aspheric, toric, and multifocal IOLs

Dr. Valery Vinzent Wittwer

Cataract surgery removes the natural crystalline lens and implants an artificial lens (IOL), both in a single operation. The refractive power of the IOL therefore has to be determined in advance. The following parameters are used to determine IOL power:

  • Axial length (AL) in millimetres
  • Keratometry values (K) in dioptres
  • Anterior chamber depth (ACD) in millimetres

For a more precise determination, newer formulas (fourth and fifth generation) also predict the anticipated IOL position in the eye (Effective Lens Position) using ray-tracing, artificial intelligence, or regression

Target refraction

  • Distance (emmetropia): focal point at distance (> 6 metres to infinity) for watching TV or driving without glasses -> 0 dioptres
  • Intermediate distance (slight myopia) for computer distance and reading the newspaper on the table, or for monovision: focal point at intermediate distance -> -1.5 dioptres (66 centimetres)
  • Reading distance (myopia) for reading books -> -2.0 (50 centimetres) to -2.5 dioptres (40 centimetres) to -3.0 dioptres (33 centimetres)
Monovision
  • Determine the dominant eye
  • Simulate monovision with a trial frame ("plug-in glasses")
    • 1. Fully correct both eyes for distance, target refraction 0 dioptres
    • 2. Correct the non-dominant eye for near with +1.5 (convex plus lens) -> target refraction -1.5 dioptres
    • 3. Simulate the opposite (dominant eye for near)
    • 4. Have the patient look into the distance (visual acuity chart) and at near (reading chart) with the trial frame
    • 5. Send the patient to the waiting room with the trial frame and instruct them to look around and walk about with it to get a spatial impression of monovision
    • 6. Evaluate the patient's feedback
      • Positive feedback: it works well, initially still unfamiliar but relatively comfortable after a few minutes -> surgery can be planned
        • Positive feedback, but: the patient is very uncertain -> contact lens trial
      • Unclear feedback: it works but feels very unfamiliar -> contact lens trial or multifocal IOLs
      • Negative feedback: neither distance nor near vision is sharp, has to close one eye to see clearly with the other, cannot judge distances -> multifocal IOLs
  • Monovision with anisometropia of more than 1.5 dioptres
    • Reduced three-dimensional perception
    • In principle only in cases of:
      • Pre-existing anisometropia
      • Amblyopia (despite the amblyopia, the amblyopic eye sees better at near than the better eye -> stimulation -> possible slight improvement in visual acuity)
  • Correcting astigmatism in monovision
    • Undercorrect the near eye (leave 0.5 dioptres of astigmatism) -> improved depth of focus
  • Caution: new anisometropia can make binocular fusion more difficult and thereby aggravate a latent squint (phoria) -> test with a trial frame, contact lens trial if necessary
  • Simulation with contact lenses
    • If the patient wants monovision but is unsure, a contact lens wearing trial should be carried out
    • From 1 dioptre of astigmatism onward, this should also be corrected by the contact lens (these contact lenses can be ordered from the opticians at any ONO eye clinic)
    • Patients with no contact lens experience can have the lenses inserted one morning and removed again that evening (possible at any ONO eye clinic)
  • "Mix and match"
    • Aspheric IOL for distance in the dominant eye
    • EDoF IOL in the non-dominant eye with a target refraction of -0.5 to -1.5 (higher-order aberrations are better tolerated in the non-dominant eye; the dominant eye has no aberrations with aspheric IOLs)

Determining spherical/aspheric IOL power

  • 22.0-24.5 mm axial length, "normal eyes"
  • < 22.0 mm axial length, "short eyes"
    • Barrett Universal II (ONO guideline)
    • Kane formula
  • > 24.5 mm axial length, "long eyes"
    • Barrett Universal II (ONO guideline)
    • Kane formula
  • Abnormal K values (<41.5, >44 dioptres)
    • Barrett Universal II (ONO guideline)
  • After corneal refractive surgery (LASIK, LASEK, PRK, transPRK)
    • ASCRS (ONO guideline)
    • Barrett Universal II
Example: aspheric IOL

The patient wants sharp distance vision after cataract surgery -> binocular distance vision (see 1-5)

The patient wants sharp distance vision with the right, dominant eye after cataract surgery and to work at the computer screen with the left eye -> monovision (see 6.) (ONO guideline: only available with the "Silver" or "Gold" package)

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1. Normal axial length (22-24.5mm)
2. Normal K values (41.5-44 dioptres)
3. Astigmatism < 0.7 dioptres
4. Right eye: IOL for emmetropia +23.0 gives a refraction of +0.06 (closest to zero)
5. Left eye: +23.0 gives a refraction of +0.09 dioptres (closest to zero)
6. Left eye (non-dominant) for monovision: +25.0 gives a refraction of -1.39 dioptres (target refraction -1.25 to -1.5 dioptres)

Determining toric (tIOL) / multifocal IOL (mfIOL) power

Prerequisites

The patient wants maximum distance visual acuity without needing glasses, or wants monovision

  • Predominantly regular astigmatism with components at 90° (steep and flat axes at right angles to each other)
  • Stable topography
    • Keratoconus is usually stable at cataract age
    • In iatrogenic keratectasia or PMD, progression must generally be assumed -> no implantation of tIOLs or mfIOLs -> evaluate corneal cross-linking
  • Good visual potential (retina/optic nerve intact)

Contraindications

  • Severely irregular cornea (keratoconus, PMD, scar, keratectasia) -> implant a spherical/aspheric IOL, with touch-up by PRK and cross-linking if needed
  • Progressive keratectasia -> cross-linking
  • Strongly fluctuating topographies -> rule out progressive keratectasia
  • Status post keratoplasty (DALK/PKP)
    • Astigmatism should be corrected at the corneal level (re-suturing, opening the interface)
    • Add-on implantation/PIOL implantation in front of the spherical/aspheric IOL if needed
  • Progressive pterygium -> 1. pterygium excision 2. wait until topography is stable (at least two topographies after three weeks and after six weeks) 3. tIOL if appropriate

EDOF IOL

  • HOA (corneal aberrometry at 6 mm pupil diameter)
    • RMS < 0.5 μm
    • Coma < 0.3
    • Spherical aberration (SA) < +/- 0.3 μm
  • Pupil size
    • 2-6 mm

mfIOL

  • HOA (corneal aberrometry at 6 mm pupil diameter)
    • RMS < 0.3-0.4 μm
    • Coma < 0.2-0.3 μm
    • Spherical aberration (SA) < +/- 0.2-0.25
  • Pupil size
    • 2-5 mm
    • Scotopic > 5mm -> increased halos/glare, reduced contrast

Sources

  • ESCRS Guidelines
  • Holladay JT, et al. JCRS 2017
  • Kohnen T, et al, Ophthalmology 2014
  • Pedrotti E, et al. Eye 2018
Example: toric IOL

The patient has corneal astigmatism in both eyes and wants binocular distance vision, i.e. sharp distance vision with both eyes
(ONO guideline: only available with the "Silver" or "Gold" package)

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1. left (OD): anterior corneal astigmatism (SimK) 1.4 dioptres, to its right anterior astigmatism minus posterior astigmatism (Total Corneal Refractive Power, TCRP) > 0.7 dioptres -> toric IOL needed
2. UDM 611 BB Toric (has a different A-constant than the non-toric UDM 611)
Right eye
3. Spherical IOL power: +19.5 gives a refraction of -0.17 (closest to zero)
4. IOL toricity of 2.0 gives a residual astigmatism of -0.1 (closest to zero) at 45°, i.e. the astigmatism is slightly overcorrected
Left eye
5. Spherical IOL power: +19.0 gives -0.02 (closest to zero)
6. IOL toricity: 2.5 gives -0.11 (closest to zero)
7. Temporal incision
8. IOL implantation axis (aligned with the steep axis, since the IOL toricity is expressed as a plus cylinder)
Correct clinical note documentation

Template "vc"

Plan: Phaco-IOL by X
Package: none/ Basic/ Vision/ Prime/ Deluxe
Goal: binocular distance vision/ near vision/ monovision
IOL: monofocal aspheric/ EDoF/ hybrid EDoF-MF
1. OX, ZR plan
2. OX, ZR plan
Caution: monocle/ HPMC 2% on the table/ claustrophobia/ allergies
ASA risk group: I/II/III
no GP report required (ASA I or II and < 70 years old)
Report to GP for premedication (ASA III or > 70 years old)

Template, worked example

Plan: Phaco-IOL by Dr. Muster in 4-6 weeks (e.g. earlier surgery in case of elevated intraocular pressure)
Package: Vision (he does not want glasses for distance vision)
Goal: binocular distance vision
IOL: Monofocal Aspheric UDM 611 BB Toric (a toric IOL is required for astigmatism of > 0.7 dioptres)
1. OS plan, +19.5/2.5/141°vw (initials of the physician who determined the IOL)
2. OD, ZR plan +19.00/2.0/45°vw
Caution: HPMC 2% on the table (due to reduced endothelial cell count)/ claustrophobia (needs more propofol)/ allergies: e.g. penicillin/iodine/latex
ASA risk group: II (has arterial hypertension and mildly elevated blood glucose, both well controlled)
No GP report required (< 70 years old) (is 69 years old)

Examples of IOL determination according to the ONO guideline

Example entry for the preoperative cataract assessment based on the "vc" template

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Corneal tomography using Pentacam®
Right eye
Assessment:  relatively regular against-the-rule astigmatism

-> toric IOL indicated

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Values for IOL calculation

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Left eye
Assessment: regular against-the-rule astigmatism

-> toric IOL indicated

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Topography data

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IOL calculation with Pentacam ALX®

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Example of a biometry with incision
Structured approach to IOL determination

1. Overview

  • Check that the incision is correct (temporal, superior, superotemporal)
  • Implantation axis = steep axis, i.e. plus cylinder (refraction is always expressed as minus cylinder -> flat axis)

2. Determining the spherical component of the IOL

  • as close to zero as possible (here +22.0 dioptres -> target refraction -0.09)

3. Determining toricity

  • IOL toricity of 1.0, 1.5, 2.25 dioptres -> astigmatism is undercorrected -> negative residual astigmatism remains on the refraction axis
  • as close to zero as possible, even if this results in a slight overcorrection (this is absolutely contraindicated when fitting glasses, but not with IOLs)
    • 3.0 dioptres -> astigmatism is slightly overcorrected -> the axis of the residual astigmatism therefore rotates 90° to 4° (corresponding to the steep implantation axis)
    • the implantation axis is primarily determined by the steep axis (K2, example below: K2=0°) and may deviate from it slightly depending on the SIA (astigmatism induced by the incision) (see IOL axis=4°)
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1. Overview sketch: superotemporal incision for a right-handed surgeon (light blue), implantation axis (here 4°)
2. Determining the sphere: +22.0 -> -0.09 (i.e. mild myopia)
3. Determining toricity

After corneal refractive surgery

Ablation of the cornea changes its curvature, i.e. the K values, which means that the usual formulas for IOL calculation are no longer accurate.

Several formulas take these changes into account. The ESCRS IOL calculation platform uses several formulas simultaneously, depending on which data are available. The more data available, the more accurate the calculation.
Ideally, the patient's old K values and spectacle prescription should be obtained from them to optimise the calculation.

-> ASCRS® IOL Calculator

Select the type of refractive surgery

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left: IOL calculation after LASIK/PRK for myopia
middle: for hyperopia
right: after radial keratotomy

Fill in the form for the IOL calculation
-> Vertex distance 12 mm
-> Device Keratometric Index (n) 1.3375

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1. Physician and patient details
2. Pre-LASIK/PRK data (from old records)
3. Post-LASIK/PRK data (current measurements) -> for Pentacam® see below
4. Biometry data

Pentacam®
-> From the topography -> corneal power distribution -> True Net Power at 4.0 mm

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-> take from the biometry (important: internal AC depth, i.e. anterior chamber depth internal)

Special considerations

If, due to a previous refractive procedure, the patient has a decentred or small optical zone, it is advisable to aim the target refraction slightly towards hyperopia. A resulting hyperopic ablation profile is in this case better suited to regularising and enlarging the topography in a further step by means of excimer laser ablation (retreatment).

In keratoconus/PMD

  • Kane formula

Which IOL for which patient

Normal cornea

  • normal prolate (Q > 0)
  • Spherical aberration: +0.27 μm
  • Q value: -0.2 to -0.3
  • -> aspheric IOL with negative spherical aberration (e.g. -0.2 to -0.27)
    • Better visual quality
      • more contrast sensitivity, less glare, particularly at dusk and at night
      • especially in patients with large (scotopic) pupils

Abnormal cornea

  • hyperprolate (Q value < -0.4)
  • Spherical aberration low or even negative
  • e.g. after myopic LASIK/PRK
  • -> neutral-aspheric or spherical IOL

Spherical IOL

  • For corneas with negative spherical aberration (normal prolate corneas, steeper centrally than peripherally, Q value < 0.0 (average value +0.27 um)
    • after corneal refractive surgery (particularly myopia correction)
    • if positive spherical aberration is desired -> slightly increased depth of focus
    • in cases of increased decentration risk (less sensitive to decentration/tilt)

With blue-light filter

Suitable for all patients

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