12.2.2025
Reading time:
6 minutes

YAG laser

Yttrium aluminum garnet laser (Nd:YAG) treatments

Dr. Valery Vinzent Wittwer

The YAG laser is a solid-state laser which uses a crystal and emits radiation with a wavelength of approximately 1064 µm (infrared range), which leads to photodisruption. This can be used to alter or tear tissue in the eye.

YAG capsulotomy

Indication: posterior capsule opacification, capsular phimosis, before refractive touch-up for residual ametropia after cataract surgery (e.g. Touch Up)

Preparation

Inform the patient and have the consent form signed

Maximally dilate the pupil with tropicamide eye drops (Mydriaticum dispersa®) 3x every 10 minutes, if necessary using Mydriasert

In known glaucoma or endothelial damage (e.g. Fuchs endothelial dystrophy): apraclonidine (e.g. Iopidine® 1%) or brimonidine (e.g. Alphagan® 2mg/ml) or dorzolamide (e.g. Dorzo-Vision® 2%) eye drops once during preparation

Laser settings

Energy: 1-3 mJ (start low and slowly increase until the capsule is torn)
Pulse: 1
Mode: fm
Focus:

  • Without contact lens: posterior defocus (Ellex® 500um),
  • With contact lens: defocus 300um (Volk YAG Capsulotomy®)
    • Oxybuprocaine eye drops 1x
    • Hydroxypropyl methylcellulose 2-3% (HPMC, Methocel sol. 2%®)

Pattern: cross/star with enlarging shots (no circle -> optically disturbing)

The capsulotomy must be at least as large as the mesopic pupil.

Post-operative treatment:

  • Total energy applied < 100mJ: NSAID eye drops (e.g. Yellox) 2x/day for 1 week
  • Total energy applied > 100 mJ: prednisolone eye drops 4x/day for 4 days, 2x for 3 days, 2x for 2 days, 1x for 1 day
Follow-up

Check-up after 1 week with autorefraction and tonometry

If applicable, combined with YAG capsulotomy of the fellow eye (direct dilation)

Sources

  • Barnes EA et al. Ophthalmology. 2004;111(7):1393–1397. PMID: 15234143.

YAG capsulotomy for capsular phimosis

Indication

Progressive contraction of the anterior capsulorhexis after cataract surgery with:

  • Narrowing of the rhexis opening affecting the optical axis, with reduced visual acuity or dysphotopsia
  • IOL decentration or tilt, deformation/compression
Preparation

Inform the patient and have the consent form signed

Maximally dilate the pupil with tropicamide eye drops (Mydriaticum dispersa®) 3x every 10 minutes, if necessary using Mydriasert

In known glaucoma or endothelial damage (e.g. Fuchs endothelial dystrophy): apraclonidine eye drops (e.g. Iopidine 1%) or brimonidine eye drops (e.g. Alphagan 2mg/ml) or dorzolamide (e.g. Dorzo-Vision 2%) once during preparation

Laser settings

Energy: 2-3 mJ (start low and slowly increase until the fibrotic anterior capsule is torn)
Pulse: 1
Mode: fm
Focus:

  • Without contact lens: anterior defocus (Ellex® 100-200um),
  • With contact lens: no defocus (Volk YAG Capsulotomy®)
    • Oxybuprocaine eye drops 1x
    • Hydroxypropyl methylcellulose 2-3% (HPMC, Methocel sol. 2%®)
Treatment technique

Pattern: place at least 3 radial relaxing incisions in the fibrotic anterior capsule. If tension is present, the phimosis tears posteriorly and the optical axis enlarges.

The capsulotomy must be at least as large as the mesopic pupil.

Therapy and follow-up
  • Total energy applied < 100mJ: NSAID eye drops (e.g. Yellox) 2x/day for 1 week
  • Total energy applied > 100 mJ: prednisolone eye drops 4x/day for 4 days, 2x for 3 days, 2x for 2 days, 1x for 1 day

Check-up after 1 week with autorefraction and tonometry; further treatment may be necessary. If applicable, combined with treatment of the fellow eye (direct dilation)

Sources

  • Hayashi K et al. Am J Ophthalmol. 2008;146:23–30. PMID: 18405874.

YAG-LIT (laser iridotomy)

Indication: primary angle-closure glaucoma and prophylaxis of the fellow eye, secondary angle-closure glaucoma (pupillary block), plateau iris syndrome, malignant glaucoma

Inform the patient and have the consent form signed

Constrict the pupil: apraclonidine 1% eye drops (Iopidine 0.5-1%®) once and pilocarpine (Spersacarpine 2%®) eye drops once within 10 minutes

Laser settings and preparation

Energy: 4-7mJ (start low and slowly increase until the iris tissue is torn through)
Pulse: 3
Mode: fm
Focus: 0 (no defocus) on an iris crypt (fewer vessels)
Contact lens: (Volk Irid YAG®/Abraham YAG Iridotomy Lens®)

  • Oxybuprocaine 0.4% eye drops 1x (Oxybuprocaine®)
  • Hydroxypropyl methylcellulose 2-3% (HPMC, Methocel sol. 2%®)
Procedure

Perform the iridotomy superotemporally (fewer glare and ghost images, as it is covered by the upper lid) until penetration into the posterior chamber (transillumination)

If bleeding occurs from the iris tissue, reapply the contact lens and apply gentle pressure for 60 seconds or until hemostasis

Therapy and follow-up

Intraocular pressure check after 1 hour and gonioscopy to assess the angle

Post-operative treatment: prednisolone eye drops 4x/day for 4 days, 2x for 3 days, 2x for 2 days, 1x for 1 day

YAG-SLT (selective laser trabeculoplasty)

Indication: existing primary open-angle glaucoma and poor compliance with eye drop application (possible as first-line treatment)
Lowers intraocular pressure by approximately 20-30% (equivalent to one active ingredient of a pressure-lowering eye drop)

Laser settings and preparation

Energy: 0.6-0.9 mJ (deep, until "champagne bubbles" become visible) (less energy with more pigmentation)
Fixed (Ellex): size 400 um, 3 ns)

Focus: 0 (no defocus) on an iris crypt (fewer vessels)
Contact lens: (Latina SLT Gonio Laser Lens, Goldmann 3-mirror contact lens, Ritch Trabeculoplasty Lens)

  • Oxybuprocaine 0.4% eye drops 1x (e.g. Oxybuprocaine®)
  • Hydroxypropyl methylcellulose 2-3% (HPMC, Methocel sol. 2%®)
Procedure

Confluent laser spots over the pigmented trabecular meshwork, 50-100 spots over 180°-360°

Therapy and follow-up

Intraocular pressure check after 30-60 minutes (pressure spikes possible)

  • If IOP > 21 -> acetazolamide (Diamox) 250mg tablet once

Post-operative treatment: alpha-agonist eye drops (e.g. Alphagan) 1x, prednisolone eye drops (e.g. Pred Forte) 4x/day for 4 days, 2x for 3 days, 2x for 2 days, 1x for 1 day
Continue existing glaucoma eye drops until 6 weeks, then reduce

Follow-up with the referring physician after 4-6 weeks

Repetition: SLT can be repeated if the effect wanes. No maximum number of repetitions is defined; clinical evidence for efficacy is available for up to three SLT treatments.

Sources

  • Gazzard et al. Ophthalmology. 2023;130:139–151. PMID: 36122660.
  • Jang et al. J Curr Glaucoma Pract. 2021;15:117–124. PMID: 35173393.

YAG vitreolysis

Laser device: Ellex laser (Ultra Q Reflex, Ultra Q Reflex Neo, Tango Reflex, Tango Reflex Neo)
Contact lens: Volk Singh Mid-Vitreous, Ocular Karickhoff Off-Axis Vitreous
Energy: 3-4 mJ, titrate up to max. 10 mJ (the more posterior, the more energy needed)

Indication (patient selection)

Vitreous opacities

  • clinically significant (e.g. visible on ultrasound or fundoscopy)
  • symptomatic (bothersome, e.g. when driving, reading, etc.) for > 6 months
  • stable for at least three months
  • dense, sharply demarcated opacities (e.g. Weiss ring) are easier to treat than diffuse opacities

Relative contraindication (treat with caution)

  • High myopia -> increased risk of retinal tear or detachment
  • Advanced glaucoma -> risk of intraocular pressure spike

Absolute contraindications

  • Current symptomatic posterior vitreous detachment (positive dysphotopsia) -> increased risk of retinal tear or detachment
  • Simultaneous laser treatment (e.g. capsulotomy)
  • Opacity located outside the safety zone (3mm anterior to the retina or posterior to the lens)
Preparation

Tropicamide eye drops 3x and phenylephrine eye drops 2x, oxybuprocaine eye drops 2x (alternating every 3-5 minutes)

Procedure

1. Use on-axis (coaxial) and off-axis illumination to identify and localize the opacity and to adjust the intensity of the red reflex

2. Decide whether the opacity lies within the safety zone

  1. Start with low energy (3mJ), then slowly increase if necessary up to 10 mJ until optical breakdown and vaporization of the vitreous collagen occurs. Initially, the number of pulses should not exceed 300-400 (300-2000 mJ). Visibility may worsen due to the resulting gas bubbles.
  2. Order: anterior to posterior, superior to inferior
  3. Move the eye to bring opacities into zones that are easier and safer to treat
  4. Caution
    1. Do not fire when the retina is also in focus (i.e. appears sharp)
    2. Special care is required when treating near the retina or lens (at least 3mm safety margin), particularly at higher energies
Post-operative course

Recommendations: no restrictions necessary; black spots, especially in the lower visual field, correspond to air bubbles that resolve within a few days.
Post-operative treatment: Yellox eye drops 2x/day / Nevanac 3mg eye drops 1x/day / Nevanac 1mg eye drops 3x/day for 1 week
Intraocular pressure measurement 30 minutes after treatment
Follow-up after 3-7 days, repeat treatment if necessary (multiple treatments are usually required)

Sources

  • Shah & Heier. JAMA Ophthalmol. 2017;135:918–923. PMID 28727887.
  • Hahn et al. JAMA Ophthalmol. 2017;135:973–976. PMID 28750116.
  • Shah & Heier. Ophthalmic Surg Lasers Imaging Retina. 2020;51:85–88. PMID 32084280.

You might also be interested in this

General

Overview of the structure, function and diseases of the eye

The most important sensory organ in humans accounts for 70-80% of all sensory impressions. Vision requirements and demands are constantly increasing.
General

Side effect of medication on the eye

Various active ingredients of drugs can cause eye side effects. If you feel that a medication is harming your eyes, it makes sense to see an ophthalmologist
General

Low vision - visual aids

Simple tricks and aids can make the lives of visually impaired people worth living again